Misoprostol (Cytotec)

Use: Treatment of early pregnancy loss, incomplete abortion, or missed abortion

Effects:

Applies to misoprostol: oral tablet.

• Misoprostol administration to women who are pregnant can cause birth defects, abortion, premature birth, or uterine rupture.Uterine rupture has been reported when misoprostol was administered in pregnant women to induce labor or to induce abortion.
• The risk of uterine rupture increases with advancing gestational ages and with prior uterine surgery, including Cesarean delivery.
• Misoprostol should not be taken by pregnant women to reduce the risk of ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs).
• Patients must be advised of the abortifacient property and warned not to give the drug to others.
• Misoprostol should not be used for reducing the risk of NSAID-induced ulcers in women of childbearing potential unless the patient is at high risk of complications from gastric ulcers associated with use of the NSAID, or is at high risk of developing gastric ulceration.
• In such patients, misoprostol may be prescribed if the patient: has had a negative serum pregnancy test within 2 weeks prior to beginning therapy; is capable of complying with effective contraceptive measures; has received both oral and written warnings of the hazards of misoprostol, the risk of possible contraception failure, and the danger to other women of childbearing potential should the drug be taken by mistake; will begin misoprostol only on the second or third day of the next normal menstrual period.